Nicotine enhances neovascularization and promotes tumor growth.

摘要: Solid tumors require vascularization for their growth. Bone marrow-derived endothelial progenitor cells participate in tumor angiogenesis. Here, we show that nicotine markedly accelerated growth of colon cancer inoculated subcutaneously mice but had no effect on proliferation carcinoma vitro. We found the was associated with increased and bone contributed to formation new blood vessels. Our findings promotes growth, at least part, by stimulating tumor-associated neovascularization.