Overview of Specific Molecular Targeted Agents for Combined Modality Therapy

摘要: Despite recent advances in the technology and techniques for delivering radiotherapy to patients with malignancies, inability of maximally tolerated doses radiation locally eradicate all malignant cells remains a major clinical problem leading failure overall treatment plan. As described by Rosen et al., there are variety reasons why tumors recur after (1–3). A “geographic miss” occurs when portion observable tumor volume is excluded from port those receive nominal dose radiation. Frequently, distribution gross uneven, central targeted receiving higher quantity than at peripheral tumor/normal tissue interface. These edge therefore can subtherapeutic or sublethal retain ability regrow repopulate. This referred as “marginal miss.” Irradiated tissues also potentially be recolonized regional anatomic sites hematogenous dissemination. “repopulation.” However, cause local recurrence tolerable dosages completely eliminate within mass. Radioresistance this sense relative, since presumably that would kill if toxicity factors inherent host did not preclude its delivery.