Frequent activation of mammalian target of rapamycin in primary lung adenocarcinoma and preinvasive lesion

摘要: Background and aim: The mammalian target of rapamycin (mTOR) pathway is important for cell survival, growth proliferation may be involved in the histological progression lung adenocarcinoma (AC). Methods: We compared expression mTOR signal molecules, i.e., phosphorylated m-TOR (p-mTOR), phosphatase tensin homolog deleted on chromosome ten (PTEN), epidermal factor receptor (EGFR), cyclin D1, among AC, situ (AIS) including both pure bronchioloalveolar carcinoma (BAC) peripheral BAC-like lesions around invasive carcinoma, atypical adenomatous hyperplasia (AAH), normal parenchyma surrounding tumor by immunohistochemistry. protein was also correlated with patients’ clinicopathological data smoking history, stage at diagnosis, recurrence survival. Results: Intermediate or strong immunoreactivity p-mTOR seen 84.1% AC 90.2% AIS. Partial complete loss PTEN demonstrated 88.8% 30.4% A significant trend increasing EGFR, PTEN, p53 Ki-67 labeling index were observed from AAH to through Expression associated status. Conclusions: Activation can occur various stimuli an early event carcinogenesis sex status patient.