Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

作者: Steven Belinsky , John Brognard , Sandra M. Swain , Curtis Harris , Amy S. Clark

DOI: 10.1172/JCI16147

关键词:

摘要: Tobacco-related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400,000 deaths per year occurring in the US. Genotoxic effects of tobacco …

参考文章(48)
J. Tonder, P. Olesen, Agonists at the a4b2 Nicotinic Acetylcholine Receptors Relationships and Molecular Modelling Current Medicinal Chemistry. ,vol. 8, pp. 651- 674 ,(2001) , 10.2174/0929867013373165
C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry. ,vol. 269, pp. 5241- 5248 ,(1994) , 10.1016/S0021-9258(17)37680-9
Takeshi Kihara, Shun Shimohama, Hideyuki Sawada, Kazuhiro Honda, Tomoki Nakamizo, Hiroshi Shibasaki, Toshiaki Kume, Akinori Akaike, α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity Journal of Biological Chemistry. ,vol. 276, pp. 13541- 13546 ,(2001) , 10.1074/JBC.M008035200
John D Minna, R. Maneckjee, Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth & Differentiation. ,vol. 5, pp. 1033- 1040 ,(1994)
Christopher Heeschen, James J. Jang, Michael Weis, Anjali Pathak, Shuichiro Kaji, Robert S. Hu, Philip S. Tsao, Frances L. Johnson, John P. Cooke, Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis Nature Medicine. ,vol. 7, pp. 833- 839 ,(2001) , 10.1038/89961
Arno D. J. Maus, Edna F. R. Pereira, Peter I. Karachunski, Robert M. Horton, Duraiswamy Navaneetham, Kevin Macklin, Wellington S. Cortes, Edson X. Albuquerque, Bianca M. Conti-Fine, Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors Molecular Pharmacology. ,vol. 54, pp. 779- 788 ,(1998) , 10.1124/MOL.54.5.779
Y. Wang, E. F. R. Pereira, A. D. J. Maus, N. S. Ostlie, D. Navaneetham, S. Lei, E. X. Albuquerque, B. M. Conti-Fine, Human Bronchial Epithelial and Endothelial Cells Express α7 Nicotinic Acetylcholine Receptors Molecular Pharmacology. ,vol. 60, pp. 1201- 1209 ,(2001) , 10.1124/MOL.60.6.1201
Dario R. Alessi, Margaret A. Lawlor, PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? Journal of Cell Science. ,vol. 114, pp. 2903- 2910 ,(2001) , 10.1242/JCS.114.16.2903
Hans-Peter Gerber, Amy McMurtrey, Joe Kowalski, Minhong Yan, Bruce A. Keyt, Vishva Dixit, Napoleone Ferrara, Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway Journal of Biological Chemistry. ,vol. 273, pp. 30336- 30343 ,(1998) , 10.1074/JBC.273.46.30336
K. Podsypanina, R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, P. Frost, V. Dreisbach, J. Blenis, Z. Gaciong, P. Fisher, C. Sawyers, L. Hedrick-Ellenson, R. Parsons, An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 10320- 10325 ,(2001) , 10.1073/PNAS.171060098