Schizophrenia and the alpha7 nicotinic acetylcholine receptor.
作者： Laura F. Martin , Robert Freedman
DOI: 10.1016/S0074-7742(06)78008-4
关键词:
摘要: In addition to the devastating symptoms of psychosis, many people with schizophrenia also suffer from cognitive impairment. These lead marked dysfunction and can impact employability, treatment adherence, social skills. Deficits in P50 auditory gating are associated attentional impairment may contribute perceptual disturbances. This nicotinic cholinergic-mediated inhibitory process represents a potential new target for therapeutic intervention schizophrenia. chapter will review evidence implicating cholinergic, specifically, alpha7 receptor system pathology Impaired sensory has been linked gene on chromosome 15q14 locus. A majority persons heavy smokers. Although nicotine acutely reverse diminished schizophrenia, this effect is lost chronic basis due desensitization. The agonist 3-(2,4 dimethoxy)benzylidene-anabaseine (DMXBA) enhance animal models. DMXBA well tolerated humans study found that enhances both cognition. Nicotinic acetylcholine agonists appear be viable candidates disturbances
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