Behavioral animal models of antipsychotic drug actions.

摘要: Basic research in animals represents a fruitful approach to study the neurobiological basis of brain and behavioral disturbances relevant neuropsychiatric disease establish evaluate novel pharmacological therapies for their treatment. In context schizophrenia, there are models employing specific experimental manipulations developed according pathophysiological or etiological hypotheses. The use selective lesions adult acute administration psychotomimetic agents indispensable tools elucidation contribution regions neurotransmitters genesis symptom collection symptoms enjoy some degrees predictive validity. However, they may be inaccurate, if not inadequate, capturing mechanisms ontology needed complete understanding limited discovery compounds treatment negative cognitive schizophrenia. Under prevailing consensus schizophrenia as neurodevelopmental origin, we have seen establishment animal which aim identify processes whereby brain, following triggering events, develops into “schizophrenia-like brain” over time. Many such neonatal ventral hippocampus (vHPC) lesion, methylazoxymethanol (MAM), prenatal immune activation can mimic broad spectrum behavioral, cognitive, abnormalities directly implicated schizophrenic disease. These allow screens against multiple coexisting schizophrenia-related dysfunctions while incorporating disease-relevant concept abnormal development. multiplicity existing is testimonial multifactorial nature ample opportunities integration. Indeed, one ultimate goal must incorporate successes distinct unitary account complex disorder approaches further development evaluation antipsychotic strategies.