Molecular pathology of lung cancer
作者： Luisa M. Solis , Ignacio I. Wistuba
DOI: 10.1007/978-1-4419-0787-5_14
关键词: Anaplastic lymphoma kinase 、 Lung cancer 、 Molecular pathology 、 Cancer research 、 Medicine 、 Epidermal growth factor receptor 、 Cancer 、 Targeted therapy 、 Gene mutation 、 Gene duplication
摘要: This overview of the molecular pathology of lung cancer includes a review of the most salient molecular alterations of the genome, transcriptome, and the epigenome. The insights provided by the growing use of next-generation sequencing (NGS) in lung cancer will be discussed, and interrelated concepts such as intertumor heterogeneity, intratumor heterogeneity, tumor mutational burden, and the advent of liquid biopsy will be explored. Moreover, this work describes how the evolving field of molecular pathology refines the …
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