Oncogenic Mutations of PIK3CA in Human Cancers
作者： Yardena Samuels , Victor E. Velculescu
DOI: 10.4161/CC.3.10.1164
关键词:
摘要: The involvement of the PIK3CA gene product p110α, catalytic subunit phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 years, and support this proposal had provided by both genetic functional studies, including most recently discovery common activating missense mutations a wide variety tumor types. This chapter will focus on these describes their relevance to range
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Philip E. LeBoit, Eva-Bettina Bröcker, Boris C. Bastian, Henning Hamm, Dan Pinkel, Chromosomal Gains and Losses in Primary Cutaneous Melanomas Detected by Comparative Genomic Hybridization Cancer Research. ,vol. 58, pp. 2170- 2175 ,(1998)
Do-Sun Byun, Kyucheol Cho, Byung-Kyu Ryu, Min-Goo Lee, Jae-Il Park, Kwon-Seok Chae, Hyo-Jong Kim, Sung-Gil Chi, Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. International Journal of Cancer. ,vol. 104, pp. 318- 327 ,(2003) , 10.1002/IJC.10962
Laleh Shayesteh, Yiling Lu, Wen-Lin Kuo, Russell Baldocchi, Tony Godfrey, Colin Collins, Daniel Pinkel, Bethan Powell, Gordon B. Mills, Joe W. Gray, PIK3CA is implicated as an oncogene in ovarian cancer Nature Genetics. ,vol. 21, pp. 99- 102 ,(1999) , 10.1038/5042
Guojun Wu, Mingzhao Xing, Elizabeth Mambo, Xin Huang, Junwei Liu, Zhongmin Guo, Aditi Chatterjee, David Goldenberg, Susanne M Gollin, Saraswati Sukumar, Barry Trink, David Sidransky, Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Research. ,vol. 7, pp. 1- 8 ,(2005) , 10.1186/BCR1262
Jin Jen, Steve M Powell, Nickolas Papadopoulos, Kelly J Smith, Stanley R Hamilton, Bert Vogelstein, Kenneth W Kinzler, None, Molecular Determinants of Dysplasia in Colorectal Lesions Cancer Research. ,vol. 54, pp. 5523- 5526 ,(1994)
Vivian Li, Chi Wong, Tsun Chan, Agnes Chan, Wei Zhao, Kent-Man Chu, Samuel So, Xin Chen, Siu Yuen, Suet Leung, None, Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer. ,vol. 5, pp. 29- 29 ,(2005) , 10.1186/1471-2407-5-29
V. Ahrenkiel, P. Guldberg, A. F. Kirkin, A. Birck, J. Zeuthen, P. Thor Straten, Disruption of the MMAC1/PTEN Gene by Deletion or Mutation Is a Frequent Event in Malignant Melanoma Cancer Research. ,vol. 57, pp. 3660- 3663 ,(1997)
Yen-Ying Ma, Sung-Jen Wei, Yu-Chen Lin, Jia-Chyi Lung, Ting-Chang Chang, Jacqueline Whang-Peng, Jacqueline M Liu, Deng-Mei Yang, Wen K Yang, Chen-Yang Shen, PIK3CA as an oncogene in cervical cancer Oncogene. ,vol. 19, pp. 2739- 2744 ,(2000) , 10.1038/SJ.ONC.1203597
P. J. Morin, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. ,vol. 275, pp. 1787- 1790 ,(1997) , 10.1126/SCIENCE.275.5307.1787
Bertrand Actor, J.M.J. Ludwig Cobbers, Rainer Büschges, Marietta Wolter, Christiane B. Knobbe, Guido Reifenberger, Ruthild G. Weber, Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. Genes, Chromosomes and Cancer. ,vol. 34, pp. 416- 427 ,(2002) , 10.1002/GCC.10087