Molecular Determinants of Dysplasia in Colorectal Lesions

摘要: One hallmark of malignant potential is dysplasia, the disruption normal morphology. While it generally recognized that cancer result a series genetic changes, relationship these alterations and their timing to advent dysplasia remains obscure. To address this issue, 54 small benign colorectal lesions various were analyzed for APC K-RAS mutations, two which have been implicated in early stages tumorigenesis. mutations closely associated with dysplasia. In contrast, found be remarkably common nondysplastic apparently limited progress larger tumors. These results provide evidence nature order changes can specific impact on both tumor morphology (e.g., dysplasia) likelihood progression.