摘要: Publisher Summary This chapter introduces colorectal cancer that constitutes a major public health problem. Of all types, the molecular changes leading to malignant growth are perhaps best known in carcinoma. Considerable progress has been made defining critical mutations and gene expression pathogenesis. Several of genetic alterations identified thus far frequently seen most common type tumors. The majority tumors (85%) sporadic origin, yet they exhibit close similarities resulting from inherited syndromes. A feature is instability, with frequency allele loss up 20% evaluable chromosome arms.
sci-hub.se 参考文章(96)
M.J Duffy, A van Dalen, C Haglund, L Hansson, R Klapdor, R Lamerz, O Nilsson, C Sturgeon, O Topolcan, Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines. European Journal of Cancer. ,vol. 39, pp. 718- 727 ,(2003) , 10.1016/S0959-8049(02)00811-0
Dominique Wendum, Pierre-Yves Boëlle, Valérie Rigau, Nicole Sebbagh, Sylviane Olschwang, Najat Mourra, Rolland Parc, Germain Trugnan, Joëlle Masliah, Jean-François Fléjou, Mucinous colon carcinomas with microsatellite instability have a lower microvessel density and lower vascular endothelial growth factor expression Virchows Archiv. ,vol. 442, pp. 111- 117 ,(2003) , 10.1007/S00428-002-0737-3
Thomas Knösel, Youngwei Yu, Ulrike Stein, Holger Schwabe, Karsten Schlüns, Peter Michael Schlag, Manfred Dietel, Iver Petersen, Overexpression of c-erbB-2 protein correlates with chromosomal gain at the c-erbB-2 locus and patient survival in advanced colorectal carcinomas Clinical & Experimental Metastasis. ,vol. 19, pp. 401- 407 ,(2002) , 10.1023/A:1016368708107
Rozypal Tl, Korourian S, Kechelava S, Kelly T, West Kw, SEPRASE, A MEMBRANE-BOUND PROTEASE, IS OVEREXPRESSED BY INVASIVE DUCTAL CARCINOMA CELLS OF HUMAN BREAST CANCERS Modern Pathology. ,vol. 11, pp. 855- 863 ,(1998)
Hussam H. Mady, Mona F. Melhem, FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study. Clinical & Experimental Metastasis. ,vol. 19, pp. 351- 358 ,(2002) , 10.1023/A:1015594702522
Barbara N. Vietmeier, Gisela Brünagel, Robert H. Getzenberg, Anthony J. Bauer, Robert E. Schoen, Identification of Nuclear Matrix Protein Alterations Associated with Human Colon Cancer Cancer Research. ,vol. 62, pp. 2437- 2442 ,(2002)
John R. Goldblum, William R. Hart, Preetha Ramalingam, Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. Implications for the pathogenesis of perianal Paget disease associated with rectal adenocarcinoma Archives of Pathology & Laboratory Medicine. ,vol. 125, pp. 1074- 1077 ,(2001) , 10.1043/0003-9985(2001)125<1074:CSIIRA>2.0.CO;2
Jin Jen, Steve M Powell, Nickolas Papadopoulos, Kelly J Smith, Stanley R Hamilton, Bert Vogelstein, Kenneth W Kinzler, None, Molecular Determinants of Dysplasia in Colorectal Lesions Cancer Research. ,vol. 54, pp. 5523- 5526 ,(1994)
Xiao-Feng Sun, p73 overexpression is a prognostic factor in patients with colorectal adenocarcinoma. Clinical Cancer Research. ,vol. 8, pp. 165- 170 ,(2002)
J. R. Jass, Towards a molecular classification of colorectal cancer. International Journal of Colorectal Disease. ,vol. 14, pp. 194- 200 ,(1999) , 10.1007/S003840050211