Phosphatidylinositol 3-Kinase: The Oncoprotein
作者： Peter K. Vogt , Jonathan R. Hart , Marco Gymnopoulos , Hao Jiang , Sohye Kang
DOI: 10.1007/82_2010_80
关键词: Kinase 、 Phosphatidylinositol 、 Protein subunit 、 Phosphatidylinositol 3-Kinases 、 Oncogenicity 、 Receptor tyrosine kinase 、 Mutation 、 P110α 、 Biology 、 Biochemistry
摘要: The catalytic and regulatory subunits of class I phosphoinositide 3-kinase (PI3K) have oncogenic potential. The catalytic subunit p110α and the regulatory subunit p85 undergo …
springer.com
sci-hub.se 
researchgate.net 参考文章(181)
R. Dhand, I. Hiles, G. Panayotou, S. Roche, M.J. Fry, I. Gout, N.F. Totty, O. Truong, P. Vicendo, K. Yonezawa, PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. The EMBO Journal. ,vol. 13, pp. 522- 533 ,(1994) , 10.1002/J.1460-2075.1994.TB06290.X
Bellacosa A, Tsichlis Pn, Gonzalez-Portal Me, Datta K, Franke Tf, Taguchi T, Ahmed Nn, Testa, The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene. ,vol. 8, pp. 1957- 1963 ,(1993)
Luciano Pirola, Marketa J. Zvelebil, Genevieve Bulgarelli-Leva, Emmanuel Van Obberghen, Michael D. Waterfield, Matthias P. Wymann, Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα) FUNCTIONS OF LIPID KINASE-DEFICIENT PI3Kα IN SIGNALING Journal of Biological Chemistry. ,vol. 276, pp. 21544- 21554 ,(2001) , 10.1074/JBC.M011330200
Yardena Samuels, Victor E. Velculescu, Oncogenic Mutations of PIK3CA in Human Cancers Cell Cycle. ,vol. 3, pp. 1221- 1224 ,(2004) , 10.4161/CC.3.10.1164
C L Carpenter, B C Duckworth, K R Auger, B Cohen, B S Schaffhausen, L C Cantley, Purification and characterization of phosphoinositide 3-kinase from rat liver. Journal of Biological Chemistry. ,vol. 265, pp. 19704- 19711 ,(1990) , 10.1016/S0021-9258(17)45429-9
Osman Nidai Ozes, Lindsey D Mayo, Jason A Gustin, Susan R Pfeffer, Lawrence M Pfeffer, David B Donner, None, NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase Nature. ,vol. 401, pp. 82- 85 ,(1999) , 10.1038/43466
Luis Rodríguez-Borlado, Domingo F. Barber, Carmen Hernández, Miguel A. Rodríguez-Marcos, Arsenio Sánchez, Emilio Hirsch, Matthias Wymann, Carlos Martínez-A., Ana C. Carrera, Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio. Journal of Immunology. ,vol. 170, pp. 4475- 4482 ,(2003) , 10.4049/JIMMUNOL.170.9.4475
Khaled Ali, Montserrat Camps, Wayne P. Pearce, Hong Ji, Thomas Rückle, Nicolas Kuehn, Christian Pasquali, Christian Chabert, Christian Rommel, Bart Vanhaesebroeck, Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo Journal of Immunology. ,vol. 180, pp. 2538- 2544 ,(2008) , 10.4049/JIMMUNOL.180.4.2538
D. R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B. A. Hemmings, Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal. ,vol. 15, pp. 6541- 6551 ,(1996) , 10.1002/J.1460-2075.1996.TB01045.X
Serge Roche, J. Downward, Patrick Raynal, Sara A. Courtneidge, A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction Molecular and Cellular Biology. ,vol. 18, pp. 7119- 7129 ,(1998) , 10.1128/MCB.18.12.7119