Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo

摘要: The leukocyte-enriched p110γ and p110δ isoforms of PI3K have been shown to control in vitro degranulation mast cells induced by cross-linking the high affinity receptor IgE (FceRI). However, relative contribution these IgE-dependent allergic responses vivo is controversial. A side-by-side comparative analysis role cell function, using genetic approaches newly developed isoform-selective pharmacologic inhibitors, confirms that both play an important FceRI-activated vitro. In vivo, however, only was found be required for optimal IgE/Ag-dependent hypersensitivity mice. These observations identify as a key therapeutic target among allergy- cell-related diseases.