PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms

摘要: Cardiovascular diseases are the most common cause of death around world. This includes atherosclerosis and adverse effects its treatment, such as restenosis thrombotic complications. The development these arterial pathologies requires a series highly-intertwined interactions between immune cells, leading to specific inflammatory fibroproliferative cellular responses. In last few years, study phosphoinositide 3-kinase (PI3K) functions has become an attractive area investigation in field diseases, especially since inhibitors PI3K isoforms have been developed. family 8 members divided into classes I, II or III depending on their substrate specificity. Although some different responsible for production same 3-phosphoinositides, they each specific, non-redundant result differences expression levels cell types, activation mechanisms subcellular locations. review will focus that suspected having protective deleterious both various cells types found wall. It also discuss our current understanding context which isoform(s) should be targeted future therapeutic interventions prevent treat diseases.