Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
作者： Khaled Ali , Antonio Bilancio , Matthew Thomas , Wayne Pearce , Alasdair M. Gilfillan
DOI: 10.1038/NATURE02991
关键词:
摘要: Inflammatory substances released by mast cells induce and maintain the allergic response1,2. Mast cell differentiation activation are regulated, respectively, stem factor (SCF; also known as Kit ligand) allergen in complex with allergen-specific immunoglobulin E (IgE)2,3. Activated SCF receptors high-affinity for IgE (FcɛRI) engage phosphoinositide 3-kinases (PI(3)Ks) to generate intracellular lipid second messenger signals2,3,4,5. Here, we report that genetic or pharmacological inactivation of p110δ isoform PI(3)K leads defective SCF-mediated vitro proliferation, adhesion migration, impaired allergen–IgE-induced degranulation cytokine release. Inactivation protects mice against anaphylactic responses. These results identify a new target therapeutic intervention allergy mast-cell-related pathologies.
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