Phosphoinositides in Chemotaxis

摘要: Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators a wide array biological responses. In particular, their role in regulation cell migration has been extensively studied and extends to amoeboid as well mesenchymal migration. Through emergence fluorescent probes that target PI3K products use specific inhibitors knockout technologies, spatio-temporal distribution chemotaxing cells shown represent anterior polarity signal targets downstream effectors actin polymerization. addition, intricate cross-talk networks have regulate signals control posterior effectors. Yet, more complex environments or conditions where chemoattractant gradients steep, variety types can still chemotax absence signals. Indeed, parallel transduction pathways coordinately directed movement. this chapter, we will review current play various types, highlight importance mathematical modeling study chemotaxis, end with brief overview other signaling cascades known also chemotaxis.