Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer Progression
作者： Joseph J. Provost , Mark A. Wallert
DOI: 10.1111/CBDD.12035
关键词: Ezrin 、 Regulator 、 Intracellular 、 Moesin 、 Biology 、 Radixin 、 Tumor progression 、 Gene isoform 、 Signal transduction 、 Cell biology
摘要: The sodium hydrogen exchanger isoform one is a critical regulator of intracellular pH, serves as an anchor for the formation cytoplasmic signaling complexes, and modulates cytoskeletal organization. There growing interest in potential therapeutic target against cancer. Sodium transport drives membrane protrusions essential cell migration contributes to establishment tumor microenvironment that leads rearrangement extracellular matrix further supporting progression. Here, we focus on impact inexpensive, $100 genome would have identifying prospective targets treat tumors based upon changes gene expression variation regulators. In particular, will ezrin, radixin, moesin family proteins, calcineurin B homologous Ras/Raf/MEK/ERK signaling, phosphoinositide they relate regulation cancer
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