The PTEN/PI3 Kinase Pathway in Human Glioma

摘要: Phosphoinositide 3-kinase (PI3K) was discovered over 20 years ago as an enzyme that active in growth factor-stimulated and oncogene-transformed cells. Ten later, the PTEN gene isolated by its deletion a large proportion of human cancers, including glioblastoma. These two areas research converged when it shown dephosphorylated lipid product PI3K activity, phosphatidylinositol (3,4,5) trisphosphate, or PIP3. Furthermore, has since become clear tumor-suppressive activities are independent phosphatase activity. This chapter reviews importance activity development glioblastoma, describing different genetic epigenetic alterations occur to deregulate this pathway. It will also describe regulation expression transcriptional posttranslational processes. Recent results implicating cells thought initiate early brain tumor (brain stem cells) reviewed. Finally, possibilities using pathway both direct therapeutic target way predicting response recently developed drugs discussed.