The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
David Stokoe , Lawrence P. Kane , Arthur Weiss , Zheng Xu
Cell Growth & Differentiation 13 ( 7) 285 -296
79
2002
p27Kip1 is required for PTEN-induced G1 growth arrest.
Daniel Basila , Daphne A. Haas-Kogan , David Stokoe , Christian H. Brandts
Cancer Research 61 ( 5) 2105 -2111
85
2001
Dysregulation of PTEN and Protein Kinase B Is Associated with Glioma Histology and Patient Survival
Kathleen R. Lamborn , Daniel Basila , Ralph P. Ermoian , Daphne A. Haas-Kogan
Clinical Cancer Research 8 ( 5) 1100 -1106
163
2002
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
W. K.Alfred Yung , David Stokoe , Xianjun Fang , Gordon B. Mills
Cancer Research 58 ( 23) 5285 -5290
213
1998
Loss of PTEN facilitates HIF-1-mediated gene expression
Amato J. Giaccia , Albert Koong , Wayne Zundel , Eunice Chen
Genes & Development 14 ( 4) 391 -396
1,172
2000
Genomic Copy Number Analysis of Non-small Cell Lung Cancer Using Array Comparative Genomic Hybridization Implications of the Phosphatidylinositol 3-Kinase Pathway
Adam B. Olshen , Patrick A. Treseler , Daniel Polikoff , David M. Jablons
Cancer Research 62 ( 13) 3636 -3640
216
2002
Dominant p110α activation in endometrial cancer.
Kevan Shokat , Zachary Knight , Frank McCormick , David Stokoe
Molecular Cancer Therapeutics 6
2007
Protein phosphorylation drug discovery summit--SRI conference. Targeting kinases and phosphatases for novel therapeutics. 3-5 March 2003, San Diego, CA, USA.
David Stokoe
IDrugs : the investigational drugs journal 6 ( 5) 432 -436
2003
PIK3CA mutations frequently coexist with PTEN mutations in endometrial cancer and overexpression of ERBB2 and/or ERBB3 in breast cancer
Yuji Taketani , Katsutoshi Oda , Jennifer Okada , Takeshi Jimbo
Cancer Research 66 345 -345
2006
Abstract B23: Crucial deubiquitinases in cancer cell survival
Lorna Kategaya , Trinna Cuellar , Ben Haley , Jinfeng Liu
Clinical Cancer Research 23
2017
A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.
Nicholas Dompe , Christiaan Klijn , Sara A. Watson , Katherine Leng
PLOS ONE 13 ( 6)
9
2018
Abstract B90: Understanding the effects of RAF inhibitors on RAF signaling in B‐RAF V600E mutant versus wild type tumors
Ivana Yen , Kyung Song , David Stokoe , Barbara Brandhuber
Molecular Cancer Therapeutics 8
1
2009
Ras–MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells
Ho-June Lee , Yi Cao , Victoria Pham , Elizabeth Blackwood
Molecular Cancer Therapeutics 16 ( 4) 694 -704
8
2017
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
David Stokoe , Katrin Engel , David G. Campbell , Philip Cohen
FEBS Letters 313 ( 3) 307 -313
507
1992
The phosphoinositide 3-kinase pathway and cancer.
David Stokoe
Expert Reviews in Molecular Medicine 7 ( 10) 1 -22
42
2005
Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance
Terry D Crawford , Steffan Vartanian , Alexandre Côté , Steve Bellon
Bioorganic & Medicinal Chemistry Letters 27 ( 15) 3534 -3541
25
2017
Phosphorylation of p16INK4A correlates with Cdk4 association.
Jay Gump , David Stokoe , Frank McCormick
Journal of Biological Chemistry 278 ( 9) 6619 -6622
40
2003
Selektive Inhibierung von mutiertem Ras‐Protein durch kovalent bindende Liganden
Joachim Rudolph , David Stokoe
Angewandte Chemie 126 ( 15) 3851 -3853
6
2014
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou , Kyung Song , Ivana Yen , Barbara J. Brandhuber
Nature 464 ( 7287) 431 -435
1,239
2010
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.
Clodagh O'Shea , Kristina Klupsch , Serah Choi , Bridget Bagus
The EMBO Journal 24 ( 6) 1211 -1221
105
2005