Selektive Inhibierung von mutiertem Ras‐Protein durch kovalent bindende Liganden
作者： Joachim Rudolph , David Stokoe
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sci-hub.se 参考文章(9)
Weiru Wang, Guowei Fang, Joachim Rudolph, Ras inhibition via direct Ras binding--is there a path forward? Bioorganic & Medicinal Chemistry Letters. ,vol. 22, pp. 5766- 5776 ,(2012) , 10.1016/J.BMCL.2012.07.082
F. Shima, Y. Yoshikawa, M. Ye, M. Araki, S. Matsumoto, J. Liao, L. Hu, T. Sugimoto, Y. Ijiri, A. Takeda, Y. Nishiyama, C. Sato, S. Muraoka, A. Tamura, T. Osoda, K.-i. Tsuda, T. Miyakawa, H. Fukunishi, J. Shimada, T. Kumasaka, M. Yamamoto, T. Kataoka, In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 8182- 8187 ,(2013) , 10.1073/PNAS.1217730110
J Way, Covalent modification as a strategy to block protein-protein interactions with small-molecule drugs. Current Opinion in Chemical Biology. ,vol. 4, pp. 40- 46 ,(2000) , 10.1016/S1367-5931(99)00049-6
Carolyn D. Britten, PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types Cancer Chemotherapy and Pharmacology. ,vol. 71, pp. 1395- 1409 ,(2013) , 10.1007/S00280-013-2121-1
Hans Robert Kalbitzer, Ina C. Rosnizeck, Claudia E. Munte, Sunilkumar Puthenpurackal Narayanan, Veronika Kropf, Michael Spoerner, Intrinsische allosterische Hemmung von Signalproteinen durch Stabilisierung gering besetzter, durch Hochdruck-NMR-Spektroskopie nachweisbarer Interaktionszustände† Angewandte Chemie. ,vol. 125, pp. 14492- 14496 ,(2013) , 10.1002/ANGE.201305741
S. Gysin, M. Salt, A. Young, F. McCormick, Therapeutic strategies for targeting ras proteins. Genes & Cancer. ,vol. 2, pp. 359- 372 ,(2011) , 10.1177/1947601911412376
Jonathan M. Ostrem, Ulf Peters, Martin L. Sos, James A. Wells, Kevan M. Shokat, K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions Nature. ,vol. 503, pp. 548- 551 ,(2013) , 10.1038/NATURE12796
Sang Min Lim, Kenneth D. Westover, Scott B. Ficarro, Rane A. Harrison, Hwan Geun Choi, Michael E. Pacold, Martin Carrasco, John Hunter, Nam Doo Kim, Ting Xie, Taebo Sim, Pasi A. Jänne, Matthew Meyerson, Jarrod A. Marto, John R. Engen, Nathanael S. Gray, Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor† Angewandte Chemie. ,vol. 53, pp. 199- 204 ,(2014) , 10.1002/ANIE.201307387
Hans Robert Kalbitzer, Ina C. Rosnizeck, Claudia E. Munte, Sunilkumar Puthenpurackal Narayanan, Veronika Kropf, Michael Spoerner, Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High‐Pressure NMR Spectroscopy Angewandte Chemie. ,vol. 52, pp. 14242- 14246 ,(2013) , 10.1002/ANIE.201305741