Protein tyrosine kinase receptors.

摘要: More than 50 PTK receptors are known to be involved in regulation of cell growth, differentiation, chemotaxis and actin reorganization. can classified into subfamilies according their structural features. activated by ligand induced homo- or heterodimerization, which leads receptor autophosphorylation on tyrosine residues. In certain receptors, the regulates catalytic activity kinase. Moreover, autophosphorylated residues bind signal transduction molecules with SH2 PTP domains. Such actual binding phosphorylation There also examples constitutively active that translocated act at membrane receptors. this way, specific intracellular pathways initiated. After activation, internalized deactivated dephosphorylation as well degradation cytoplasm lysosomes.