Induction of apoptosis in the presence of natural polyphenols and expression profile of K-Ras and Akt1 in breast cancer cell line MDA-MB-231

摘要: One of the vital process by which cellular homeostasis is maintained Apoptosis. In normal cells this program well balanced. But any alteration in genetic and epigenetic leads to loss key properties like proliferation, differentiation, invasion, adhesion, hence opened gateway for complex set disease known as cancer. Moreover, RAS/MEK/ERK PI3K/AKT signaling cascade most frequently mutated pathway human Oncogenic mutations these deregulation several effecter pathways that control cell survival, apoptosis migration, thus promote malignant transformation. As all natural polyphenols have anti- cancer property some extent, we aimed at investigating effect curcumin EGCG combination with other conventional chemotherapeutic agents are used a lot targeted therapies, potentially working synergistically increasing therapeutic drugs combat against So present study aims deciphering role on induction apoptosis, inhibition proliferation change expression level oncogenes K-Ras Akt1 breast lines. A brief can help pile valuable information developing better interventions