Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
作者： John D. Minna , Adi Gazdar , Joyce E. Ohm , Denise Juroske , Jonathan R. Pollack
DOI:
关键词: EGFR inhibitors 、 Erlotinib 、 ERBB3 、 Epidermal growth factor receptor 、 Tyrosine kinase 、 Cancer research 、 Gefitinib 、 EGFR Gene Amplification 、 Biology 、 Cyclin-dependent kinase 8
摘要: Epidermal growth factor receptor (EGFR) is occasionally amplified and/or mutated in non–small cell lung cancer (NSCLC) and can be coexpressed with other members of the HER …
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V. Rusch, Ethan Dmitrovsky, C. Cordon-Cardo, S. Hoda, M. Zaman, Jonathan M Kurie, J. Mcintosh, J. Baselga, J. Orazem, Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung Cancer Research. ,vol. 53, pp. 2379- 2385 ,(1993)
David Solit, Mark M. Moasser, Qing-Bai She, Andrea Basso, Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling Clinical Cancer Research. ,vol. 9, pp. 4340- 4346 ,(2003)
Roberto Bianco, Incheol Shin, Christoph A Ritter, F Michael Yakes, Andrea Basso, Neal Rosen, Junji Tsurutani, Phillip A Dennis, Gordon B Mills, Carlos L Arteaga, Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors Oncogene. ,vol. 22, pp. 2812- 2822 ,(2003) , 10.1038/SJ.ONC.1206388
Shiquan Liu, Wenjing Liu, John L. Jakubczak, Gregory L. Erexson, Kenneth R. Tindall, Richard Chan, William J. Muller, Sankar Adhya, Susan Garges, Glenn Merlino, Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 3770- 3775 ,(2002) , 10.1073/PNAS.052710299
Raffaella Sordella, Daphne W Bell, Daniel A Haber, Jeffrey Settleman, Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways Science. ,vol. 305, pp. 1163- 1167 ,(2004) , 10.1126/SCIENCE.1101637
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938
Steffan N. Ho, Henry D. Hunt, Robert M. Horton, Jeffrey K. Pullen, Larry R. Pease, Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene. ,vol. 77, pp. 51- 59 ,(1989) , 10.1016/0378-1119(89)90358-2
Joseph Schlessinger, Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor Cell. ,vol. 110, pp. 669- 672 ,(2002) , 10.1016/S0092-8674(02)00966-2
Mark G. Kris, Ronald B. Natale, Roy S. Herbst, Thomas J. Lynch, Jr, Diane Prager, Chandra P. Belani, Joan H. Schiller, Karen Kelly, Harris Spiridonidis, Alan Sandler, Kathy S. Albain, David Cella, Michael K. Wolf, Steven D. Averbuch, Judith J. Ochs, Andrea C. Kay, Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients with Non-Small Cell Lung Cancer: A Randomized Trial JAMA. ,vol. 290, pp. 2149- 2158 ,(2003) , 10.1001/JAMA.290.16.2149
Valerie Rusch, Ethan Dmitrovsky, Irina Linkov, David Klimstra, Aberrant Expression of p53 or the Epidermal Growth Factor Receptor Is Frequent in Early Bronchial Neoplasia, and Coexpression Precedes Squamous Cell Carcinoma Development Cancer Research. ,vol. 55, pp. 1365- 1372 ,(1995)