Aberrant Expression of p53 or the Epidermal Growth Factor Receptor Is Frequent in Early Bronchial Neoplasia, and Coexpression Precedes Squamous Cell Carcinoma Development

摘要: New strategies are needed for the detection and treatment of lung cancer must derive from a fuller understanding carcinogenesis. Frequent molecular genetic abnormalities occur in non-small cell (NSCLC), but little is known about which these precede an invasive carcinoma. We examined expression p53, epidermal growth factor receptor (EGFR), transforming alpha, most common NSCLC, preneoplastic bronchial lesions. Primary NSCLC associated lesions were identified by retrospective review resected tumors at this center. Expression carcinomas, lesions, normal contrasted using immunohistochemistry. Thirty-four with 62 identified. The included 15 squamous carcinomas (SCCs) 19 non-SCCs. Bronchial areas metaplasia (n = 14), inflammatory atypia 19), dysplasia 17), carcinoma situ 12). Nineteen (56%) 10 (16%) exhibited aberrant p53 immunostaining, whereas 18 (53%) 30 (48%) showed abnormal EGFR immunostaining. Positive staining alpha was seen 16 (47%) occurred inconsistently epithelium. Only p53. Aberrant not specific type or although there trend toward increased relative to atypia. All one simultaneously showing SCC. conclude that: (a) variably expressed respiratory epithelium as well reactive lesions; (b) present metaplastic epithelium; (c) occurs both preinvasive may be early marker neoplastic transformation; (d) simultaneous predominantly SCC their These findings indicate that frequent neoplasia, coexpression predispose development lung.