7.08 – Kinase Inhibitors for Cancer

摘要: In the 15 years since last edition of Comprehensive Medicinal Chemistry, our understanding signal transduction processes mediated by kinase enzyme cascades, in both health and disease, has increased substantially. The number publications area resources devoted to research on kinases have also grown, reflect importance this target class modern approaches treating cancer. It is clear that perturbation normal systems plays a key role development progression tumors, restoring signaling through appropriate inhibition offers an attractive treatment option for wide variety human tumors. Since cells tumor often appear respond differently inhibition, targets cancer may help avoid or reduce many common side effects associated with conventional cytotoxic therapies while providing effective therapy. This chapter attempts cover progress made identifying small-molecule inhibitors all major presently seen as important text includes brief description disease its characteristics, followed relevance involved further organized according type being discussed, groups related are described within smaller sections. Each section discusses links between cancer, goes describe been developing kinases, refers structural mechanistic information, if it available, how helps properties inhibitors. highlights compounds progressed clinical studies implications any feedback be before final view potential future opportunities issues area. backed up comprehensive up-to-date list supporting references individual provide access review articles covering