The ras signalling pathway as a target in cancer therapy.
作者： Kathryn Graham , Michael F. Olson
DOI: 10.1007/978-3-540-31209-3_8
关键词:
摘要: The Ras GTPase proteins and their down-stream effectors regulate specific intracellular signalling pathways involved in numerous biological processes. Their actions directly influence progression through the cell cycle delicate balance of pro- anti-apoptotic factors. variety functions controlled by Ras, emerging evidence indicating that aberrations as well at multiple points downstream contribute to tumourigenesis, suggest signal transduction mechanisms have significant potential anti-cancer therapeutic targets.
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