Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells.

摘要: Cervical cancer ranks seventh overall among all types of in women. Although several treatments, including radiation, surgery and chemotherapy, are available to eradicate or reduce the size cancer, many cancers eventually relapse. Thus, it is essential identify possible alternative therapeutic approaches for cancer. We sought effective approaches, by first synthesizing palladium nanoparticles (PdNPs), using a novel biomolecule called saponin. The synthesized PdNPs were characterized analytical techniques. They significantly spherical shape, with an average 5 nm. Recently, gained much interest various therapies cells. Similarly, histone deacetylase inhibitors known play vital role anti-proliferative activity, gene expression, cell cycle arrest, differentiation apoptosis Therefore, we selected trichostatin A (TSA) studied their combined effect on cervical Cells treated either TSA showed dose-dependent viability. combinatorial effect, tested 50 nM nMPdNPs, had more dramatic inhibitory viability, than alone. combination pronounced cytotoxicity, oxidative stress, mitochondrial membrane potential (MMP), caspase-3/9 activity expression pro- anti-apoptotic genes. Our data show strong synergistic interaction between treatment increased demonstrated relevant targeted therapy Furthermore, provide evidence combinatory cytotoxicity mechanism