High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten+/− Mice
作者： Vuk Stambolic , David Macpherson , William B. Chapman , Ming-Sound Tsao , Akira Suzuki
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摘要: PTEN is one of the most commonly mutated tumor suppressor genes in human cancer. mutations have been implicated development a variety neoplasia, including high-grade glioblastoma, prostate, breast, endometrial, and thyroid carcinoma. Germ-line cause Cowden's syndrome (CS), multiple hamartoma condition resulting increased susceptibility for When more than 6 months old, pten+/- mice develop range tumors, partially resembling spectrum neoplasia observed CS patients. One-half (32 65) females developed breast whereas all (65 had endometrial hyperplasia, there was high incidence (14 Hamartoamous tumors gastrointestinal tract, as well prostate adrenal were also frequently observed. Significantly, overlaps with types detected The majority exhibit loss heterozygosity at pten locus, which indicates importance function formation. Consistent role negative regulation PKB/Akt phosphorylation activity, accompanied by hyperphosphorylation tumors. Taken together, our results establish an excellent animal model system investigation PTEN-related syndromes, carcinogenesis.
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