Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.
作者： Marian S. Blazes , Kathleen R. Cho , Steven I. Wang , Ramon Parsons , Shikha Bose
DOI:
关键词:
摘要: Loss of heterozygosity of chromosome 10q has been reported in approximately 40% of endometrial carcinomas. PTEN, a candidate tumor suppressor gene located at chromosome …
aacrjournals.org参考文章(8)
K R Cho, T D Kessis, L Hedrick, R T Burks, Microsatellite instability in endometrial carcinoma. Oncogene. ,vol. 9, pp. 1163- 1166 ,(1994)
Jan V. Bokhman, Two pathogenetic types of endometrial carcinoma Gynecologic Oncology. ,vol. 15, pp. 10- 17 ,(1983) , 10.1016/0090-8258(83)90111-7
Michael H. Jones, Yusuke Nakamura, Sumiko Koi, Lkuno Fujimoto, Katsuhiko Hasumi, Kyoto Kato, Allelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: Frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p Genes, Chromosomes and Cancer. ,vol. 9, pp. 119- 123 ,(1994) , 10.1002/GCC.2870090207
S Markowitz, J Wang, L Myeroff, R Parsons, L Sun, J Lutterbaugh, R. Fan, E Zborowska, K. Kinzler, B Vogelstein, al. et, Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability Science. ,vol. 268, pp. 1336- 1338 ,(1995) , 10.1126/SCIENCE.7761852
J. Huang, N. Papadopoulos, A. J. McKinley, S. M. Farrington, L. J. Curtis, A. H. Wyllie, S. Zheng, J. K. Willson, S. D. Markowitz, P. Morin, K. W. Kinzler, B. Vogelstein, M. G. Dunlop, APC mutations in colorectal tumors with mismatch repair deficiency Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 9049- 9054 ,(1996) , 10.1073/PNAS.93.17.9049
Danny Liaw, Debbie J. Marsh, Jing Li, Patricia L. M. Dahia, Steven I. Wang, Zimu Zheng, Shikha Bose, Katherine M. Call, Hui C. Tsou, Monica Peacoke, Charis Eng, Ramon Parsons, Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Nature Genetics. ,vol. 16, pp. 64- 67 ,(1997) , 10.1038/NG0597-64
David G. Mutch, Thomas J. Herzog, Paul J. Goodfellow, Deborah J. Gersell, Doris J. Tribune, Stacia L. Peiffer, Allelic Loss of Sequences from the Long Arm of Chromosome 10 and Replication Errors in Endometrical Cancers Cancer Research. ,vol. 55, pp. 1922- 1926 ,(1995)
Takayuki Enomoto, Masami Fujita, Masaki Inoue, Taisei Nomura, Kenneth R. Shroyer, Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado. American Journal of Clinical Pathology. ,vol. 103, pp. 224- 230 ,(1995) , 10.1093/AJCP/103.2.224