Allelic Loss of Sequences from the Long Arm of Chromosome 10 and Replication Errors in Endometrical Cancers

摘要: Thirty-seven endometrial cancers were subjected to an allelotype analysis in attempt identify chromosomal regions that are lost a significant portion of tumors and characterized by replication errors. Thirty-nine highly polymorphic microsatellite markers representing all arms, excluding the X short arms acrocentrics, examined. An average 20 informative cases evaluated for each marker. Genetic alterations detected 30 37 tumors. Replication errors identified 8 tumor specimens. Loss heterozygosity was observed loci on chromosomes examined with exception 4 20. The two most frequent sites loss at marker 10q (40%) 17p (29%). Six additional simple sequence repeat from genotyped effort refine region loss. chromosome 10 used these studies physically mapped use panel somatic hybrids retain defined portions 10. patterns sequences suggest role suppressor gene 10q23–26 development or progression cancers.