Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis.

摘要: Farnesyl transferase inhibitors induce G2/M cell cycle delays that cannot be explained by inhibition of the Ras GTPase. Recently, kinetochore protein Cenp-F has been shown to farnesylated. Here, we show ectopic expression targeting domain progression through G2/M. Significantly, this is dependent on CAAX farnesylation motif. We also localisation nuclear envelope at and kinetochores in prometaphase both its motif farnesyl activity. Strikingly, activity required for degradation after mitosis. Thus, these observations suggest not only but timely In addition, raise possibility anti-proliferative effects induced may due function and/or turnover.