CAAX-box protein, prenylation process and carcinogenesis

作者: Jie Liao , Guang-Yu Yang , Juehua Gao

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摘要: CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and carcinogenesis. As an important modulator of biological activity, signal transduction via protein prenylation is a crucial step for most functions, particularly anchoring these to membrane system. With better understanding the molecular mechanisms intracellular messaging this process, may be particular importance elucidating biologic events carcinogenesis provide potential approaches selectively blocking downstream cascade that allows Here, we mainly focus on process clinically box proteins, their biomarker or preventive/therapeutic target

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