Characterization of the Antitumor Effects of the Selective Farnesyl Protein Transferase Inhibitor R115777 in Vivo and in Vitro

作者: Caroline J. Fuery , Tanya L. Applegate , Walter Wouters , Gerard Sanz , Marc Venet

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摘要: R115777{(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone}is a potent and selective inhibitor of farnesyl protein …

参考文章(41)
R. Plattner, M. J. Anderson, K. Y. Sato, C. L. Fasching, C. J. Der, E. J. Stanbridge, Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 6665- 6670 ,(1996) , 10.1073/PNAS.93.13.6665
Andrew D. Hamilton, Jiazhi Sun, Yimin Qian, Saïd M. Sebti, Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion Cancer Research. ,vol. 55, pp. 4243- 4247 ,(1995)
Daitoku Sakamuro, George C. Prendergast, George C. Prendergast, Peter F. Lebowitz, Farnesyl Transferase Inhibitors Induce Apoptosis of Ras-transformed Cells Denied Substratum Attachment Cancer Research. ,vol. 57, pp. 708- 713 ,(1997)
Wei Du, Peter F. Lebowitz, George C. Prendergast, Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Molecular and Cellular Biology. ,vol. 19, pp. 1831- 1840 ,(1999) , 10.1128/MCB.19.3.1831
Ai-xue Liu, Wei Du, Jeh-Ping Liu, Thomas M. Jessell, George C. Prendergast, RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Molecular and Cellular Biology. ,vol. 20, pp. 6105- 6113 ,(2000) , 10.1128/MCB.20.16.6105-6113.2000
Myrna E. Trumbauer, Scott D. Mosser, Elaine Rands, Hema Bhimnathwala, Ian Greenberg, Allen Oliff, Charles A. Omer, Kelly Hamilton, Shobhna Gopal-Truter, Nancy E. Kohl, Edith T. Senderak, Patricia J. Miller, Timothy J. O’Neill, Howard Y. Chen, Robert B. Lobell, Michael D. Schaber, Astrid M. Kral, Kenneth S. Koblan, Jackson B. Gibbs, Ronald E. Diehl, Gina Seeburger, Dongming Liu, Michael W. Conner, Zunxuan Chen, Joseph P. Davide, Marc T. Abrams, Michelle S. Ellis, Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor Cancer Research. ,vol. 60, pp. 2680- 2688 ,(2000)
L. Gutierrez, A. I. Magee, C. J. Marshall, J. F. Hancock, Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. The EMBO Journal. ,vol. 8, pp. 1093- 1098 ,(1989) , 10.1002/J.1460-2075.1989.TB03478.X
Veeraswamy Manne, Ning Yan, Jonathan Fletcher, Thomas Glover, Bernd R. Seizinger, Carolyn Ricca, Farnesyltransferase Inhibitors Block the Neurofibromatosis Type I (NF1) Malignant Phenotype Cancer Research. ,vol. 55, pp. 3569- 3575 ,(1995)
Takeshi Nagasu, Kentaro Yoshimatsu, Cheryl Rowell, Michael D. Lewis, Ana Maria Garcia, Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Research. ,vol. 55, pp. 5310- 5314 ,(1995)