Ras-Superfamily GTP-ases in Ovarian Cancer

摘要: Small guanosine triphosphatases (GTPase), together with their associated regulators and effectors, play an important role in signal transduction pathways as of diverse cellular processes, including differentiation, cell division, proliferation, vesicle transport, nuclear assembly, cytoskeleton formation. The Ras sarcoma (Ras) oncoproteins, HRas, KRas, NRas, are the founding members Ras-related oncoprotein superfamily. Comparative genomic analyses based on sequence functional domain homology have revealed that this superfamily has more than 170 members, which can be subdivided into five major branches: Ras, Rho, Rab, Ran, Arf subfamilies. Variations structure posttranslational modifications control specific localization Ras-superfamily proteins to subcellular compartments recruitment downstream effectors allow these small GTPases function sophisticated modulators a remarkably complex range transmembrane (Ras), cytoskeletal reorganization (Rho), gene expression (Ras, Rho), intracellular trafficking (Rab, Arf), microtubule organization nucleocytoplasmic transport (Ran). Of G-proteins, subfamily is most studied, large part because critical roles human oncogenesis. Recently, Rho Rab been implicated playing cancer will also discussed review.