Role of RHOT1 on migration and proliferation of pancreatic cancer.
作者： Shasha Geng , Chengzhi He , Qingqing Li , Lei Yao , Hua Jiang
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摘要: Pancreatic cancer (PC) is one of the most malignant tumors. Rho GTPases can affect several types human cancers, including PC. In this study, we investigated role Ras homolog family member T1 (RHOT1), a new in IHC results showed that RHOT1 was expressed significantly higher PC tissues than paracancerous (P<0.01) and SMAD 4 (SMAD4) lower (P<0.01). widely cell lines analyzed by reverse transcription PCR (RT-PCR), real-time quantitative (RT-qPCR) western blotting (WB). SiRNA-RHOT1 suppressed proliferation migration SW1990 cells. Moreover, SMAD4 identified as an effector RHOT1. Our findings suggest regulate suppressing expression PC, which may provide novel sight to explore mechanism therapeutic strategy for
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