Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?
作者： Christoph W. M. Reuter , Michael A. Morgan , Lothar Bergmann
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摘要: A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These …
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K.L. MacKenzie, A. Dolnikov, M. Millington, Y. Shounan, G. Symonds, Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice Blood. ,vol. 93, pp. 2043- 2056 ,(1999) , 10.1182/BLOOD.V93.6.2043.406K17_2043_2056
R Kalra, DC Paderanga, K Olson, KM Shannon, Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras Blood. ,vol. 84, pp. 3435- 3439 ,(1994) , 10.1182/BLOOD.V84.10.3435.3435
P Corradini, M Ladetto, C Voena, A Palumbo, G Inghirami, DM Knowles, M Boccadoro, A Pileri, Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias. Blood. ,vol. 81, pp. 2708- 2713 ,(1993) , 10.1182/BLOOD.V81.10.2708.2708
Mufti Gj, Pagliuca A, Bhatt B, Layton Dm, Bailey N, Tobal K, Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia. ,vol. 4, pp. 486- 489 ,(1990)
Norton Jd, Yaxley Jc, Browett Pj, Activation of Harvey ras oncogene by mutation at codon 12 is very rare in hemopoietic malignancies. Leukemia. ,vol. 3, pp. 86- 88 ,(1989)
J.B. Gibbs, D.L. Pompliano, S.D. Mosser, E. Rands, R.B. Lingham, S.B. Singh, E.M. Scolnick, N.E. Kohl, A. Oliff, Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. Journal of Biological Chemistry. ,vol. 268, pp. 7617- 7620 ,(1993) , 10.1016/S0021-9258(18)52998-7
Andrew D. Hamilton, Jiazhi Sun, Karine Miquel, Yimin Qian, Anne Pradines, Gilles Favre, Saïd M. Sebti, GGTI-298 Induces G0-G1 Block and Apoptosis Whereas FTI-277 Causes G2-M Enrichment in A549 Cells Cancer Research. ,vol. 57, pp. 1846- 1850 ,(1997)
E. A. Elion, SIGNAL TRANSDUCTION:Routing MAP Kinase Cascades Science. ,vol. 281, pp. 1625- 1626 ,(1998) , 10.1126/SCIENCE.281.5383.1625
Heather A. Bechtold, Alphonse Krystosek, Kelley S. Fantle, Marguerite B. Dalton, Lucas DeMaio, Michael Sinensky, Robert M. Evans, The Farnesyl Protein Transferase Inhibitor BZA-5B Blocks Farnesylation of Nuclear Lamins and p21ras but Does Not Affect their Function or Localization Cancer Research. ,vol. 55, pp. 3295- 3304 ,(1995)
J K Westwick, A D Cox, C J Der, D A Brenner, M D Lewis, J J Kowalczyk, A M Garcia, The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. Journal of Biological Chemistry. ,vol. 269, pp. 19203- 19206 ,(1994) , 10.1016/S0021-9258(17)32153-1