Targeting Oncogenes Which Regulate Apoptosis
作者： Andrew C. Phillips
关键词:
摘要: Characterization of the genetic changes driving malignant phenotype has revealed that mutations promoting cell survival are common in human cancer. The increased understanding cancer at molecular level lead to development therapeutics aimed inhibiting function genes responsible for tumor phenotype. Inhibition activity oncogenes is an attractive approach already yielded some success and promises more.
springer.com
sci-hub.st 参考文章(122)
Paul G. Richardson, Teru Hideshima, Kenneth C. Anderson, Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers. Cancer Control. ,vol. 10, pp. 361- 369 ,(2003) , 10.1177/107327480301000502
Lynda Chin, Alice Tam, Jason Pomerantz, Michelle Wong, Jocelyn Holash, Nabeel Bardeesy, Qiong Shen, Ronan O'Hagan, Joe Pantginis, Hao Zhou, James W. Horner, Carlos Cordon-Cardo, George D. Yancopoulos, Ronald A. DePinho#, Essential role for oncogenic Ras in tumour maintenance Nature. ,vol. 400, pp. 468- 472 ,(1999) , 10.1038/22788
John Kuriyan, John Kuriyan, Bayard Clarkson, David Wisniewski, Bhushan Nagar, Bhushan Nagar, William G. Bornmann, Darren R. Veach, Chongyuan Liu, Thomas Schindler, Thomas Schindler, Caryl L. Lambek, Matthew A. Young, Matthew A. Young, Annabel Strife, Joseph R. Bertino, Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Research. ,vol. 62, pp. 4244- 4255 ,(2002)
Judith S. Sebolt-Leopold, David T. Dudley, Roman Herrera, Keri Van Becelaere, Amy Wiland, Richard C. Gowan, Haile Tecle, Stephen D. Barrett, Alexander Bridges, Sally Przybranowski, W.R. Leopold, Alan R. Saltiel, Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Medicine. ,vol. 5, pp. 810- 816 ,(1999) , 10.1038/10533
Celina M. D'Cruz, Edward J. Gunther, Robert B. Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golant, Robert D. Cardiff, Lewis A. Chodosh, c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations Nature Medicine. ,vol. 7, pp. 235- 239 ,(2001) , 10.1038/84691
C. Brenner, Apoptosis. Mitochondria--the death signal integrators. Science. ,vol. 289, pp. 1150- 1151 ,(2000) , 10.1126/SCIENCE.289.5482.1150
Gerard I. Evan, Karen H. Vousden, Proliferation, cell cycle and apoptosis in cancer Nature. ,vol. 411, pp. 342- 348 ,(2001) , 10.1038/35077213
Judith Dierlamm, Mathijs Baens, Iwona Wlodarska, Margarita Stefanova-Ouzounova, Jesus Maria Hernandez, Dieter Kurt Hossfeld, Christiane De Wolf-Peeters, Anne Hagemeijer, Herman Van den Berghe, Peter Marynen, None, The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas Blood. ,vol. 93, pp. 3601- 3609 ,(1999) , 10.1182/BLOOD.V93.11.3601
Kevin M. Ryan, Mary K. Ernst, Nancy R. Rice, Karen H. Vousden, Role of NF-κB in p53-mediated programmed cell death Nature. ,vol. 404, pp. 892- 897 ,(2000) , 10.1038/35009130
Andreas Gschwind, Oliver M. Fischer, Axel Ullrich, The discovery of receptor tyrosine kinases: targets for cancer therapy. Nature Reviews Cancer. ,vol. 4, pp. 361- 370 ,(2004) , 10.1038/NRC1360