Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

作者: Sally Cowley , Hugh Paterson , Pauline Kemp , Christopher J Marshall

DOI: 10.1016/0092-8674(94)90133-3

关键词:

摘要: … of neurite formation in PC12 or frk-PC12 ceils and EGFinduced … The experiment was also performed using wild-type PC12 … than MAPKK, PC12-HER ceils were coinjected with Ala-221 …

参考文章(56)
Chao-Feng Zheng, Kun-Liang Guan, None, Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues The EMBO Journal. ,vol. 13, pp. 1123- 1131 ,(1994) , 10.1002/J.1460-2075.1994.TB06361.X
A. C. Lloyd, H. F. Paterson, J. D. Morris, A. Hall, C. J. Marshall, p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C. The EMBO Journal. ,vol. 8, pp. 1099- 1104 ,(1989) , 10.1002/J.1460-2075.1989.TB03479.X
S. Nakielny, P. Cohen, J. Wu, T. Sturgill, MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase The EMBO Journal. ,vol. 11, pp. 2123- 2129 ,(1992) , 10.1002/J.1460-2075.1992.TB05271.X
Chao-Feng Zheng, Kun-Liang Guan, None, Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Journal of Biological Chemistry. ,vol. 268, pp. 11435- 11439 ,(1993) , 10.1016/S0021-9258(18)82142-1
D.R. Alessi, Y. Saito, D.G. Campbell, P. Cohen, G. Sithanandam, U. Rapp, A. Ashworth, C.J. Marshall, S. Cowley, Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. The EMBO Journal. ,vol. 13, pp. 1610- 1619 ,(1994) , 10.1002/J.1460-2075.1994.TB06424.X
S.K. Gupta, C Gallego, G.L. Johnson, L.E. Heasley, MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. Journal of Biological Chemistry. ,vol. 267, pp. 7987- 7990 ,(1992) , 10.1016/S0021-9258(18)42397-6
G I Evan, G K Lewis, G Ramsay, J M Bishop, Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Molecular and Cellular Biology. ,vol. 5, pp. 3610- 3616 ,(1985) , 10.1128/MCB.5.12.3610
S G Macdonald, C M Crews, L Wu, J Driller, R Clark, R L Erikson, F McCormick, Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Molecular and Cellular Biology. ,vol. 13, pp. 6615- 6620 ,(1993) , 10.1128/MCB.13.11.6615
C O Van Hooff, J C Holthuis, A B Oestreicher, J Boonstra, P N De Graan, W H Gispen, Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells Journal of Cell Biology. ,vol. 108, pp. 1115- 1125 ,(1989) , 10.1083/JCB.108.3.1115