作者: Caroline Saucier , Nathalie Rivard
DOI: 10.1007/978-90-481-8833-8_8
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摘要: The development of metastatic tumours is a complex process that consists series cellular events shift neoplastic cells from the primary tumour to distant location (Chambers et al., 2002). Cancer must first detach and invade surrounding stroma, degrade basement membrane, disseminate survive into circulatory systems, ultimately extravasate colonize new microenvironment. Research past decades has revealed redundant signalling pathways in both microenvironment govern cell invasion at site, survival bloodstream, progressive outgrowth sites. In this chapter, we highlight role growth factor receptor tyrosine kinase (RTK) progression colorectal cancer (CRC) advanced disease, with particular focus on those leading activation proliferative RAS/Mitogen-activated protein (MAPK) Phosphatidylinositol 3-kinase (PI3K)/AKT epithelial cells.