K-Ras-mediated Increase in Cyclooxygenase 2 mRNA Stability Involves Activation of the Protein Kinase B

作者: Raymond N. DuBois , Jinyi Shao , Hongmiao Sheng

DOI:

关键词: PI3K/AKT/mTOR pathwayRas Signaling PathwayAkt/PKB signaling pathwayProtein kinase BMAPK/ERK pathwaymTORC2DEPTORMolecular biologyAKT1Biology

摘要: … Given the important roles of both COX-2 and Akt in carcinogenesis, our results suggest that COX-2 is regulated by PI3K/Akt/PKB and may contribute to the neoplastic potential of the …

参考文章(36)
DuBois Rn, Morrow Jd, Beauchamp Rd, Shao J, Sheng H, Modulation of Apoptosis and Bcl-2 Expression by Prostaglandin E2 in Human Colon Cancer Cells Cancer Research. ,vol. 58, pp. 362- 366 ,(1998)
Weilin Xie, Harvey R. Herschman, Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum. Journal of Biological Chemistry. ,vol. 271, pp. 31742- 31748 ,(1996) , 10.1074/JBC.271.49.31742
Eugene S. Kandel, Nissim Hay, The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Experimental Cell Research. ,vol. 253, pp. 210- 229 ,(1999) , 10.1006/EXCR.1999.4690
Pablo Rodriguez-Viciana, Patricia H Warne, Asim Khwaja, Barbara M Marte, Darryl Pappin, Pamela Das, Michael D Waterfield, Anne Ridley, Julian Downward, Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras Cell. ,vol. 89, pp. 457- 467 ,(1997) , 10.1016/S0092-8674(00)80226-3
Michael E Katz, Frank McCormick, Signal transduction from multiple Ras effectors. Current Opinion in Genetics & Development. ,vol. 7, pp. 75- 79 ,(1997) , 10.1016/S0959-437X(97)80112-8
Paul Brennan, Jane W Babbage, Boudewijn M.T Burgering, Bernd Groner, Karin Reif, Doreen A Cantrell, Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F Immunity. ,vol. 7, pp. 679- 689 ,(1997) , 10.1016/S1074-7613(00)80388-X
Hongmiao Sheng, Christopher S. Williams, Jinyi Shao, Peng Liang, Raymond N. DuBois, R. Daniel Beauchamp, Induction of Cyclooxygenase-2 by Activated Ha-rasOncogene in Rat-1 Fibroblasts and the Role of Mitogen-activated Protein Kinase Pathway Journal of Biological Chemistry. ,vol. 273, pp. 22120- 22127 ,(1998) , 10.1074/JBC.273.34.22120
Thomas F Franke, Sung-Il Yang, Tung O Chan, Ketaki Datta, Andrius Kazlauskas, Deborah K Morrison, David R Kaplan, Philip N Tsichlis, The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase Cell. ,vol. 81, pp. 727- 736 ,(1995) , 10.1016/0092-8674(95)90534-0