Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
作者： R Yao , G. Cooper
关键词: Endocrinology 、 Mitogen-activated protein kinase kinase 、 Tropomyosin receptor kinase C 、 MAP kinase kinase kinase 、 Internal medicine 、 Growth factor receptor 、 Cyclin-dependent kinase 9 、 Platelet-derived growth factor receptor 、 Akt/PKB signaling pathway 、 ASK1 、 Biology 、 Cell biology
摘要: Nerve growth factor (NGF) induces both differentiation and survival of neurons by binding to the Trk receptor protein tyrosine kinase. Although Ras is required for differentiation, it was not NGF-mediated rat pheochromocytoma PC-12 cells in serum-free medium. However, ability NGF prevent apoptosis (programmed cell death) inhibited wortmannin or LY294002, two specific inhibitors phosphatidylinositol (Pl)-3 Moreover, platelet-derived (PDGF) prevented expressing wild-type PDGF receptor, but a mutant that failed activate Pl-3 Cell thus appears be mediated kinase signaling pathway distinct from mediates differentiation.
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