Survival factors and apoptosis
作者： Rosemary O'Connor
DOI: 10.1007/BFB0102309
关键词: Cancer research 、 Carcinogenesis 、 Biology 、 Protein kinase B 、 Haematopoiesis 、 Programmed cell death 、 Growth factor 、 Signal transduction 、 Kinase 、 Growth factor receptor 、 Immunology
摘要: This chapter will explore the role of survival factors in suppression apoptosis, and illustrate how signals play a critical both normal tumor cells. Survival necessary for development maintenance nervous system hemopoietic be surveyed. followed by detailed discussion insulin-like growth factor I (IGF-I) its receptor apoptosis. The importance from IGF-IR tumorigenesis discussed, results mutational analysis to assign domains apoptosis summarized. Finally, signal transduction pathways involved factor-signaling review roles played PI-3 kinase AKT speculate on activation these kinases might regulate apoptotic pathway.
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sci-hub.se 参考文章(143)
E.A. Harrington, M.R. Bennett, A. Fanidi, G.I. Evan, c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. The EMBO Journal. ,vol. 13, pp. 3286- 3295 ,(1994) , 10.1002/J.1460-2075.1994.TB06630.X
Melmed S, Yamashita S, Yamasaki H, Fagin J, Prager D, Yamamoto H, Webster J, Namba H, Weber M, Morita S, IGF-I receptor signalling: lessons from the somatotroph. Recent Progress in Hormone Research. ,vol. 51, pp. 189- ,(1996)
T. Chittenden, C. Flemington, A. B. Houghton, R. G. Ebb, G. J. Gallo, B. Elangovan, G. Chinnadurai, R. J. Lutz, A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. The EMBO Journal. ,vol. 14, pp. 5589- 5596 ,(1995) , 10.1002/J.1460-2075.1995.TB00246.X
Derek Le Roith, Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. The New England Journal of Medicine. ,vol. 336, pp. 633- 640 ,(1997) , 10.1056/NEJM199702273360907
A. Bellacosa, P. N. Tsichlis, M. E. Gonzalez-Portal, J. R. Testa, K. Datta, T. F. Franke, T. Taguchi, J. Gardner, Jin Quan Cheng, Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. ,vol. 8, pp. 745- 754 ,(1993)
R O'Connor, T Torigoe, JC Reed, D Santoli, Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN. Blood. ,vol. 80, pp. 1017- 1025 ,(1992) , 10.1182/BLOOD.V80.4.1017.1017
Haim Werner, Derek LeRoith, The Role of the Insulin-like Growth Factor System in Human Cancer Advances in Cancer Research. ,vol. 68, pp. 183- 223 ,(1996) , 10.1016/S0065-230X(08)60354-1
Rosemary O'Connor, Yimao Liu, Christopher Corvi, Gillian Payne, Sophie Lehar, Expression of the Insulin-like Growth Factor I Receptor C Terminus as a Myristylated Protein Leads to Induction of Apoptosis in Tumor Cells Cancer Research. ,vol. 58, pp. 570- 576 ,(1998)
C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry. ,vol. 269, pp. 5241- 5248 ,(1994) , 10.1016/S0021-9258(17)37680-9
G. Rodriguez-Tarduchy, M. K. L. Collins, A. Lopez-Rivas, I. Garcia, Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells. Journal of Immunology. ,vol. 149, pp. 535- 540 ,(1992)