Small-Molecule Receptor Tyrosine Kinase Inhibitors in Targeted Cancer Therapy
作者： Carlos García-Echeverría
DOI: 10.1385/1-59259-893-5:531
关键词:
摘要: ATP site-directed competitive and irreversible inhibitors of receptor tyrosine kinases have been extensively investigated in the search for new targeted antitumor agents. This chapter provides a comprehensive overview key results achievements three kinases, EGFR, c-Kit, FLT3, which drug discovery development activities advanced with some success. Three additional (IGF-IR, c-Met, RET) selected to illustrate opportunities challenges identification drugs tailored cancer treatment.
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