Combinatorial chemoprevention of intestinal neoplasia.

摘要: A combination of two drugs afforded remarkable protection from intestinal neoplasia in APC(Min/+) mice, a murine model human familial adenomatous polyposis (FAP). One the was sulindac, prototypical non-steroidal anti-inflammatory drug with established chemopreventative activity. The second EKI-569, newly developed, irreversible inhibitor epidermal growth factor receptor kinase. Although 100% untreated mice developed approximately 20 polyps, nearly half treated these agents no polyps at all. These results suggest powerful strategy for chemoprevention colonic neoplasia.