Antibody-mediated EGF receptor blockade as an anticancer therapy: from the laboratory to the clinic.

作者: John Mendelsohn

DOI: 10.1007/S00262-002-0354-7

关键词: Epidermal growth factorAntibodyGrowth factorCytokineReceptor blockadeMonoclonal antibodyImmunologyImmunotherapyMedicineAnticorps monoclonalPharmacology

摘要:

参考文章(54)
G. KÖHLER, C. MILSTEIN, Continuous cultures of fused cells secreting antibody of predefined specificity Nature. ,vol. 256, pp. 495- 497 ,(1975) , 10.1038/256495A0
T. Kawamoto, J. D. Sato, A. Le, J. Polikoff, G. H. Sato, J. Mendelsohn, Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 1337- 1341 ,(1983) , 10.1073/PNAS.80.5.1337
Jos?? Baselga, Steven D. Averbuch, ZD1839 (‘Iressa’) 1,2 as an Anticancer Agent Drugs. ,vol. 60, pp. 33- 40 ,(2000) , 10.2165/00003495-200060001-00004
B. Ozanne, C. S. Richards, F. Hendler, D. Burns, B. Gusterson, Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas. The Journal of Pathology. ,vol. 149, pp. 9- 14 ,(1986) , 10.1002/PATH.1711490104
J A Cooper, T Hunter, Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus. Journal of Cell Biology. ,vol. 91, pp. 878- 883 ,(1981) , 10.1083/JCB.91.3.878
Michael B. Sporn, George J. Todaro, Autocrine Secretion and Malignant Transformation of Cells New England Journal of Medicine. ,vol. 303, pp. 878- 880 ,(1980) , 10.1056/NEJM198010093031511
DRM Negri, E Tosi, O Valota, S Ferrini, A Cambiaggi, S Sforzini, A Silvani, PA Ruffini, MI Colnaghi, S Canevari, In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab') 2 bispecific monoclonal antibody British Journal of Cancer. ,vol. 72, pp. 928- 933 ,(1995) , 10.1038/BJC.1995.435
J. Baselga, L. Norton, H. Masui, A. Pandiella, K. Coplan, W. H. Miller, J. Mendelsohn, Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. Journal of the National Cancer Institute. ,vol. 85, pp. 1327- 1333 ,(1993) , 10.1093/JNCI/85.16.1327
Henning Bier, Thomas Hoffmann, Ulrich Hauser, Michael Wink, Martin Öchler, Andreas Kovar, Matthias Müser, Reinald Knecht, None, Clinical trial with escalating doses of the antiepidermal growth factor receptor humanized monoclonal antibody EMD 72 000 in patients with advanced squamous cell carcinoma of the larynx and hypopharynx Cancer Chemotherapy and Pharmacology. ,vol. 47, pp. 519- 524 ,(2001) , 10.1007/S002800000270
D. Slamon, W Godolphin, L. Jones, J. Holt, S. Wong, D. Keith, W. Levin, S. Stuart, J Udove, A Ullrich, al. et, Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. ,vol. 244, pp. 707- 712 ,(1989) , 10.1126/SCIENCE.2470152