EGFR Signaling and Radiation

摘要: The epidermal growth factor receptor (EGFR) is an ubiquitously expressed tyrosine kinase that over or mutated in a broad spectrum of epithelial cancers and serves as important regulator oncogenesis. Aberrant EGFR expression activity have been associated with uncontrolled cancer cell proliferation survival. Therefore, has considered attractive target therapy, including studies investigating the ability signaling to modulate radiation response. Two primary classes inhibitors developed recent years: monoclonal antibodies (mAbs) inhibitors. most mature clinical data date derives from anti-EGFR mAb inhibitor cetuximab combined head neck squamous carcinoma (HNSCC) provided new therapeutic option for this disease. Postulated mechanisms interaction between these two modalities include effects on cycle distribution, apoptosis, tumor repopulation, DNA damage/repair, impact vasculature. improvement control rates overall survival HNSCC prompted investigation approach other types. Here we review pertinent literature regarding therapies radiation, preclinical trial reflecting promising future directions approach.