Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer.
作者： O Dassonville , J L Formento , M Francoual , A Ramaioli , J Santini
DOI: 10.1200/JCO.1993.11.10.1873
关键词:
摘要: PURPOSETo determine the expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma to evaluate its prognostic value.MATERIALS AND METHODSEGFR was determined tumor biopsies obtained from 109 consecutive patients with cancer (100 men, nine women). Control were 94 a symetric nontumoral area same anatomic site. EGFR measured by binding assay using human recombinant iodine 125-EGF.RESULTSThe presence detectable levels found all explored tumors highly marked differences between (median, 71 fmol/mg protein; range, 2 2,302). In 93 cases, higher samples as compared healthy control zones. There no significant difference according various sites or tumoral differentiation status. distribution for stages I II III IV t...
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