The Role of the Insulin-like Growth Factor System in Human Cancer

摘要: Publisher Summary This chapter focuses on the role of insulin-like growth factor system in human cancer. The normal process and differentiation results from genetically programmed action a number different cellular extracellular factors. Derangement function one or more those agents can result pathologic phenotype, including neoplastic growth. A family factors shown to be intimately involved regulation cell as well transformation is (IGF) family. IGF-I IGF-II are mitogenic polypeptides produced largest amounts by liver secreted into circulation, where they mediate effects hormone (GH) longitudinal In addition ligands receptors, IGF comprises third category molecules, which bind IGFs circulation compartments. Six IGF-binding proteins (IGFBPs) have been characterized date. Binding receptor induces autophosphorylation. cycle consists four major phases: (1) presynthetic phase, G; (2) phase DNA synthesis, S; (3) premitotic (4) mitosis, M. IGF-I, IGF-II, insulin chemotactic for melanoma line A2058, assayed modified Boyden chamber. also gives selected examples involvement wealth information generated field, continued research efforts, both basic clinic, promise produce rational therapeutic approaches cancers involved.