Hyaluronan/RHAMM Interactions in Mesenchymal Tumor Pathogenesis

摘要: Fibrosarcoma belongs to the sarcoma cancer group, which are spindle cell malignancies of mesenchymal origin, and owe their name predominant line that is present within tumor. The extracellular matrix (ECM) a complicated structure surrounds supports cells tissues. Its main components proteoglycans, collagens, glycoproteins, hyaluronan (HA), several matrix-degrading enzymes. During progression, significant changes can be observed in structural mechanical properties ECM components. provides physical scaffold tumor attach migrate. Thus, it required for key cellular events such as motility, adhesion, proliferation, invasion, metastasis. Importantly, fibrosarcomas were shown have high content turnover including HA, fibronectin, laminin. In this review, we will focus on HA component fibrosarcoma critically discuss its role involved mechanisms during pathogenesis.