Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

摘要: The expression of proteoglycans (PGs), essential macromolecules the tumor microenvironment, is markedly altered during malignant transformation and progression. Synthesis stromal PGs affected by factors secreted cancer cells unique tumor-modified extracellular matrix may either facilitate or counteract growth solid tumors. emerging theme that this dual activity has intrinsic tissue specificity. Matrix-accumulated PGs, such as versican, perlecan small leucine-rich affect cell signaling, survival, adhesion, migration angiogenesis. Furthermore, cell-surface-associated syndecans glypicans, also modulated in both cells. Cell-surface-associated bind various are involved thereby affecting proliferation, adhesion motility. An important mechanism action offered a proteolytic processing cell-surface known ectodomain shedding syndecans; facilitates endothelial motility, protects proteases provides chemotactic gradient mitogens. However, on be for cell/cancer interplay promote Finally, abnormal PG serve biomarker progression patient survival. Enhanced understanding regulation metabolism involvement offer novel approach to therapy targeting microenvironment. In minireview, implication development progression, well their pharmacological malignancy, presented discussed.