Insulin-like growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland.
作者： Elizabeth Tonner , Gordon Allan , Lulzim Shkreta , John Webster , C. Bruce
关键词:
摘要: This study aims to investigate the mechanism by which prolactin and GH interact maintain mammary epithelial cell function in rat. IGF-I is an important survival factor for gland we have demonstrated that effects of involve IGF-I. acts increasing IGF- I whilst inhibiting expression IGFBP-5 from epithelium. During involution, when serum levels decline, dramatically upregulated it binds with high affinity preventing interaction IGF-receptor thus leading apoptosis. We identified a specific αS2-casein. milk protein has also been shown bind plasminogen its activator tissue-type (tPA) enhanced conversion plasmin. Plasmin initiator re-modelling extracellular matrix during involution. A potential between death remodelling evident observation inhibitor-I (PAI- 1). hypothesized could activate sequestration cleavage sequestering PAI- 1. support this hypothesis both inhibit tPA activity activation involuting gland. Our results suggest ECM via IGF-axis indicate novel role \( \alpha _{S_2 } \) process. now established lines transgenic mice expressing on β-lactoglobulin promoter explore greater detail.
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